Date of Award:
5-1-1987
Document Type:
Thesis
Degree Name:
Master of Science (MS)
Department:
Biology
Department name when degree awarded
Biology
Committee Chair(s)
Joseph K. K. Li
Committee
Joseph K. K. Li
Abstract
Hereditary multiple exostoses (HME) is a bone disease characterized by multiple benign bone tumors which develop only during active skeletal growth. Previous studies have demonstrated an autosornal dominant pattern of inheritance. In this study, several cellular oncogenes and human chromosomal fragments were used as probes to identify any restriction fragment length polymorphisms in the genomes of HME affected horses and humans. Sequences homologous to the human oncogenes c-fes, c-myb, c-myc, c-raf-1 and c-sis were identified in the horse genome. Polymorphisms were identified using c-raf-1 hybridized to Bam HI and Pst I digested horse DNA, but neither appeared linked to HME. An expected polymorphism was demonstrated in Bgl II digested human DNA using the chromosome 22 fragment probe pMS3-18, but there was no correlation to the inheritance of HME.
Recommended Citation
Moloney, Brian K., "An Analysis of DNA Polymorphisms in Hereditary Multiple Exostoses" (1987). Biology. 552.
https://digitalcommons.usu.edu/etd_biology/552
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