Document Type

Article

Journal/Book Title/Conference

Alzheimer's & Dementia: Translational Research & Clinical Interventions

Volume

1

Issue

1

Publisher

John Wiley & Sons, Inc.

Publication Date

5-16-2015

First Page

53

Last Page

62

Abstract

Introduction: Most Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study. Methods: This proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys. Results: Midway through the study, achievements include a 98.7% retention rate, a 96% rate of compliance with app data entry, and positive trends in behavioral change. Discussion: Participants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.

Comments

The Published article can be found at https://doi.org/10.1016/j.trci.2015.05.001

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