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Description
Cannabinoids are a group of over 144 known compounds extracted from hemp species. Tetrahydrocannabinol (THC), the psychoactive compound in hemp, and the non-psychoactive cannabidiol (CBD) are the most commonly known and most well studied cannabinoids. As cannabinoids can be sold for medicinal or recreational purposes, it's important to understand the impact of these cannabinoids on the brain. To explore the effects of cannabinoids on neural development, undifferentiated SH-SY5Y human neuroblastoma cells were used as a model of fetal neurons. SH-SY5Y cells were fully differentiated in the presence of no cannabinoids, THC, and/or CBD and analyzed for any developmental differences. In addition to the qualitative development assessment, we also explored the cytoprotective properties of THC and CBD against reactive oxidative species (ROS) on neural cells. We did not discover any difference in neuron development when exposed to THC or CBD, but we did discover a statistically significant protection against ROS when grown in the presence of CBD.
Publication Date
12-6-2022
City
Logan, UT
Keywords
cannabinoids, human neural differentiation, oxidative stress response, psychoactive compound
Disciplines
Engineering
Recommended Citation
Brothersen, Emily; Weatherston, Dillon; Young, Ashton; and Gustafson, Bryan, "Impact of Cannabinoids on Human Neural Differentiation and Oxidative Stress Response" (2022). Fall Student Research Symposium 2022. 71.
https://digitalcommons.usu.edu/fsrs2022/71