Date of Award
Master of Science (MS)
Mathematics and Statistics
Donald V. Sisson
Rex L. Hurst
Frederick J. Post
Biological assays are essentially biological experiments. To compare the potencies of treatments on an agreed scale is generally of more interest than to compare the magnitude of effects of different treatments.
The relative potency, R = a/b, is defined as the ratio of the means of two equally effective doses where a is the mean of A and bis the mean of B. It is an estimate of the potency of one preparation, A, relative to that of the other, B.
Different procedures have been proposed to obtain the values of R and its confidence interval. Three of the these methods are compared and discussed here. They utilize the coefficient of variation, Fieller's theorem, and logarithms.
Lung, Catherine H., "An Empirical Comparison of Confidence Interval for Relative Potency" (1976). All Graduate Plan B and other Reports. 1183.