Date of Award

5-2010

Degree Type

Report

Degree Name

Master of Science (MS)

Department

Biology

Committee Chair(s)

David W. Britt

Committee

David W. Britt

Committee

Anne J. Anderson

Committee

Joan E. McLean

Abstract

This report summarizes the effects of a range of Pluronics on cellular responses in bacterial and mammalian cells through a review of published findings. Effects of Pluronics on drug delivery, efflux systems, growth, and nutrition are reported for eukaryotic cells. For microbial cells, their effects on adhesion, movement, biofilm formation, energy status and secondary metabolism are discussed. Guided by findings in the literature, a series of experiments were conducted exploring the responses of a beneficial environmental soil microbe, Pseudomonas putida strain KT2440, to selected Pluronics. These results are presented. The report has four sections: an Introduction 4 that covers published literature on eukaryotic and prokaryotic cells, the results of studies on Pseudomonas putida strain KT2440 and the overall conclusion and potential future studies.

Included in

Biology Commons

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