Date of Award
5-2006
Degree Type
Thesis
Degree Name
Departmental Honors
Department
Biology
Abstract
Here we report a hitherto unknown effect of a synthetic inactivation inhibitor on inactivation in cardiac sodium channels (Nav1.5) from two different species: human and bovine. SDZ 211-93 9 stabilized the slow inactivated-state in both channels as seen by an increased steady-state probability of slow inactivation. SDZ also destabilized the fast-inactivated state and increased the amplitude of persistent currents. SDZ modulated conductance parameters, open-state fast inactivation time constants, and activation kinetics of hNav1.5, but not bNav1.5. These findings will aid future studies designed to elucidate the binding site and molecular mechanisms of inactivation inhibitors such as SDZ 211-939.
Recommended Citation
Kearl, Tyce Jeffrey, "Modulation of Fast and Slow Inactivation in Two Cardiac NAv Channel Isoforms by SDZ 211-939" (2006). Undergraduate Honors Capstone Projects. 681.
https://digitalcommons.usu.edu/honors/681
Included in
Copyright for this work is retained by the student. If you have any questions regarding the inclusion of this work in the Digital Commons, please email us at .
Faculty Mentor
Peter Ruben
Departmental Honors Advisor
Kim Sullivan