Class
Article
College
College of Science
Department
English Department
Faculty Mentor
Lisa M. Berreau
Presentation Type
Poster Presentation
Abstract
Carbon monoxide (CO) has unique therapeutic properties including anti-cancer effects. Flavonols such as 3-hydroxyflavone can release CO upon exposure to visible light. Gallium(III) also has anti-cancer properties and can replace Fe(III) in biological processes. This research was focused on synthesizing a complex of gallium(III) and 3-hydroxyflavone which can hopefully combine the anti-cancer properties of both gallium and CO. Initial attempts to synthesize the complex mimicked those of transition metal flavonol complexes using a base to deprotonate the flavonol and stirring with gallium salt. The most successful synthesis developed involved dissolving 3-hydroxyflavone and gallium nitrate in ethanol and DMSO, adjusting the pH with sodium carbonate and heating under nitrogen. The product formed in the synthesis was a bright yellow solid that was characterized by NMR, UV-vis, high resolution mass spectrometry, and elemental analysis. A qualitative test for CO showed that the product released CO after it was exposed to 420 nm light for 24 hours. This study provided evidence that it is possible to form a complex of gallium(III) and 3-hydroxyflavone. It may be possible to adjust the properties of the future complexes by modifying the structure of the flavonol.
Location
Logan, UT
Start Date
4-8-2022 12:00 AM
Included in
Synthesis of a Novel Carbon Monoxide-Releasing Gallium Flavonol Complex
Logan, UT
Carbon monoxide (CO) has unique therapeutic properties including anti-cancer effects. Flavonols such as 3-hydroxyflavone can release CO upon exposure to visible light. Gallium(III) also has anti-cancer properties and can replace Fe(III) in biological processes. This research was focused on synthesizing a complex of gallium(III) and 3-hydroxyflavone which can hopefully combine the anti-cancer properties of both gallium and CO. Initial attempts to synthesize the complex mimicked those of transition metal flavonol complexes using a base to deprotonate the flavonol and stirring with gallium salt. The most successful synthesis developed involved dissolving 3-hydroxyflavone and gallium nitrate in ethanol and DMSO, adjusting the pH with sodium carbonate and heating under nitrogen. The product formed in the synthesis was a bright yellow solid that was characterized by NMR, UV-vis, high resolution mass spectrometry, and elemental analysis. A qualitative test for CO showed that the product released CO after it was exposed to 420 nm light for 24 hours. This study provided evidence that it is possible to form a complex of gallium(III) and 3-hydroxyflavone. It may be possible to adjust the properties of the future complexes by modifying the structure of the flavonol.