Class
Article
College
College of Engineering
Department
English Department
Faculty Mentor
Yu Huang
Presentation Type
Poster Presentation
Abstract
Proteins make up most tissue scaffolding within the human body, making novel proteinaceous biomaterials highly sought-after since they can be designed to mimic the natural ECM of various tissues. Hagfish secrete a proteinaceous slime when threatened that clogs the gills of predators, and the keratin proteins found in the slime show promise as a potential tissue scaffold material. In this study, recombinant hagfish proteins were used to formulate a bioink which was crosslinked into hydrogels. Characterization of the hydrogel porosity and mechanical properties revealed a tunable nature valuable for artificial tissue scaffold engineering. The availability of in-house genetic modification of the protein and the tunability of the hydrogels through different processing methods are invaluable for producing useful hagfish protein hydrogels. The introduction of bioprinting extends the range of hagfish protein as a tissue scaffold material, with neuronal growth being the focus of this study.
Location
Logan, UT
Start Date
4-8-2022 12:00 AM
Included in
Bioprinting of Hagfish Keratin Proteins
Logan, UT
Proteins make up most tissue scaffolding within the human body, making novel proteinaceous biomaterials highly sought-after since they can be designed to mimic the natural ECM of various tissues. Hagfish secrete a proteinaceous slime when threatened that clogs the gills of predators, and the keratin proteins found in the slime show promise as a potential tissue scaffold material. In this study, recombinant hagfish proteins were used to formulate a bioink which was crosslinked into hydrogels. Characterization of the hydrogel porosity and mechanical properties revealed a tunable nature valuable for artificial tissue scaffold engineering. The availability of in-house genetic modification of the protein and the tunability of the hydrogels through different processing methods are invaluable for producing useful hagfish protein hydrogels. The introduction of bioprinting extends the range of hagfish protein as a tissue scaffold material, with neuronal growth being the focus of this study.