Class
Article
College
College of Agriculture and Applied Sciences
Department
English Department
Faculty Mentor
Justin A. Jones
Presentation Type
Oral Presentation
Abstract
Amyloids present in neurodegenerative diseases, like Alzheimer’s, have a devastating effect on neurons at a microscopic level. The aggregation of amyloid plaque in neuronal synapses prevents communication between brain cells, resulting in decreased cognitive function. The ability of amyloids to form these plaques on a microscopic scale can potentially increase the strength of silkworm silk fibers when utilized on a macroscopic scale. Amyloids, by nature, have a high beta sheet concentration that forms beta nanocrystals when incorporated into the silkworm genome via CRISPR-Cas9. Silkworm silk, with select amyloid and spider silk gene sequences, poses a strong candidate for a biosynthetic material alternative to synthetic fabrics.
Location
Logan, UT
Start Date
4-7-2022 12:00 AM
Creating Sustainable, High-Performance Silkworm Fibers Inspired by Neurodegenerative Disease (Amyloids)
Logan, UT
Amyloids present in neurodegenerative diseases, like Alzheimer’s, have a devastating effect on neurons at a microscopic level. The aggregation of amyloid plaque in neuronal synapses prevents communication between brain cells, resulting in decreased cognitive function. The ability of amyloids to form these plaques on a microscopic scale can potentially increase the strength of silkworm silk fibers when utilized on a macroscopic scale. Amyloids, by nature, have a high beta sheet concentration that forms beta nanocrystals when incorporated into the silkworm genome via CRISPR-Cas9. Silkworm silk, with select amyloid and spider silk gene sequences, poses a strong candidate for a biosynthetic material alternative to synthetic fabrics.
