Mona Soroush, Utah State University

Class

Article

College

College of Engineering

Department

Biological Engineering Department

Faculty Mentor

Keith Roper

Presentation Type

Poster Presentation

Abstract

Lateral Flow Assays (LFAs) offer rapid diagnostics, yet sensitivity remains a critical limitation. This study used a mathematical framework—the Convection-Diffusion-Reaction (CDR) equation—to optimize sensitivity by adjusting parameters such as flow velocity (U), association and dissociation rates (kon and koff), and nanoparticle valency. Our simulation results closely matched literature data (Berli & Kler, 2016), demonstrating significant enhancements in sensitivity with optimized parameters.

Location

Logan, UT

Start Date

4-8-2025 1:30 PM

End Date

4-8-2025 2:20 PM

Download

Share

COinS
 
Apr 8th, 1:30 PM Apr 8th, 2:20 PM

The Effects of the Action Rate and Binding Density on Sensitivity in Lateral Flow

Logan, UT

Lateral Flow Assays (LFAs) offer rapid diagnostics, yet sensitivity remains a critical limitation. This study used a mathematical framework—the Convection-Diffusion-Reaction (CDR) equation—to optimize sensitivity by adjusting parameters such as flow velocity (U), association and dissociation rates (kon and koff), and nanoparticle valency. Our simulation results closely matched literature data (Berli & Kler, 2016), demonstrating significant enhancements in sensitivity with optimized parameters.