Class
Article
College
College of Agriculture and Applied Sciences
Department
Animal, Dairy, and Veterinary Sciences Department
Faculty Mentor
Abby Benninghoff
Presentation Type
Poster Presentation
Abstract
The National Cancer Institute reports colorectal cancer as the leading cause of cancer death for individuals under 50 in the United States (American Cancer Society). These rates continue to rise with poor diet, microbiome dysbiosis, and gut inflammation being the primary drivers.
Our lab performs nutrient- intervention studies on DSS/AOM colitis-induced mouse models fed the total Western diet, reflective of the average American’s diet. A poor diet promotes gut microbiome dysbiosis and subsequent colitis, ultimately yielding colon cancer. We seek to understand how the introduction of a bioactive compound may lessen or promote these effects in in vivo mouse models.
The objective of this project was to develop an in vitro experimental model that representatively cultures the gut microbiome, providing deeper insight into direct interactions between bioactive compounds and the gut microbiome. This methodology will provide wider access to this field of research by using common materials found in labs.
Location
Logan, UT
Start Date
4-9-2025 1:30 PM
End Date
4-9-2025 2:20 PM
Included in
Establishing Methods for In Vitro Static Culture of Gut Microbiomes for Nutritional Intervention Studies
Logan, UT
The National Cancer Institute reports colorectal cancer as the leading cause of cancer death for individuals under 50 in the United States (American Cancer Society). These rates continue to rise with poor diet, microbiome dysbiosis, and gut inflammation being the primary drivers.
Our lab performs nutrient- intervention studies on DSS/AOM colitis-induced mouse models fed the total Western diet, reflective of the average American’s diet. A poor diet promotes gut microbiome dysbiosis and subsequent colitis, ultimately yielding colon cancer. We seek to understand how the introduction of a bioactive compound may lessen or promote these effects in in vivo mouse models.
The objective of this project was to develop an in vitro experimental model that representatively cultures the gut microbiome, providing deeper insight into direct interactions between bioactive compounds and the gut microbiome. This methodology will provide wider access to this field of research by using common materials found in labs.