Class
Article
College
College of Engineering
Department
Biological Engineering Department
Faculty Mentor
Elizabeth Vargis
Presentation Type
Poster Presentation
Abstract
Introduction
Age-Related Macular Degeneration (AMD) is the leading cause of vision loss worldwide, affecting 200 million adults over the age of 40
- Affects subretinal layers: retinal pigment epithelium (RPE), Bruch’s membrane, and choroid (Fig. 1)
Problem: Early mechanisms of AMD are not well understood; oxidative stress is often cited as a key contributing factor to the development of AMD.3 Current studies neglect to use primary RPE cells when investigating oxidative stress.
Oxidative Stress occurs when there is an imbalance between reactive oxygen species (ROS) production and cellular antioxidant defenses
- Overabundance of ROS results in damage to tissue and decrease in functionality of cell processes
Aim: Investigate the effects of hydrogen peroxide (H₂O₂) and UV on primary porcine RPE (pRPE) cells to model oxidative stress and AMD
Location
Logan, UT
Start Date
4-9-2025 3:30 PM
End Date
4-9-2025 4:20 PM
Included in
Evaluating the Effects of Oxidative Stress on Primary Retinal Pigment Epithelial Cells
Logan, UT
Introduction
Age-Related Macular Degeneration (AMD) is the leading cause of vision loss worldwide, affecting 200 million adults over the age of 40
- Affects subretinal layers: retinal pigment epithelium (RPE), Bruch’s membrane, and choroid (Fig. 1)
Problem: Early mechanisms of AMD are not well understood; oxidative stress is often cited as a key contributing factor to the development of AMD.3 Current studies neglect to use primary RPE cells when investigating oxidative stress.
Oxidative Stress occurs when there is an imbalance between reactive oxygen species (ROS) production and cellular antioxidant defenses
- Overabundance of ROS results in damage to tissue and decrease in functionality of cell processes
Aim: Investigate the effects of hydrogen peroxide (H₂O₂) and UV on primary porcine RPE (pRPE) cells to model oxidative stress and AMD