College
College of Science
Department
Chemistry and Biochemistry Department
Faculty Mentor
Lisa Berreau
Abstract
Carbon monoxide (CO) has unique therapeutic properties including anti-cancer effects. Flavonols such as 3-hydroxyflavone can release CO upon exposure to visible light. Gallium(III) also has anti-cancer properties and can replace Fe(III) in biological processes. This research was focused on synthesizing a family of complexes with gallium(III) bound to 3-hydroxyflavone and similar ligands which can hopefully combine the anti-cancer properties of both gallium and CO. These complexes follow a simple synthesis and the flavonols are easily modified to optimize their properties. Several of these complexes have been made with varying degrees of solubility. Each of these complexes have been confirmed to release CO using a colorimetric PdCl2 reduction test.
Document Type
Poster
Publication Date
1-25-2023
Recommended Citation
Ashton, Joel, "Developing Cancer Treatments With a One-Two Punch of a Metal and Carbon Monoxide" (2023). Research on Capitol Hill. Paper 127.
https://digitalcommons.usu.edu/roch/127