Location
Orbital ATK Conference Center
Start Date
5-7-2018 11:05 AM
Description
Increased sensitivity of glucose sensors is important for enabling detection of very low glucose concentrations, such as that found in saliva. Free-standing, vertically-aligned carbon nanotubes (VACNTs) were patterned into 16 μm diameter microchannel arrays and then functionalized for flow-through electrochemical glucose sensing. Platinum nanowires (PNs) were deposited onto VACNT surfaces. The enzyme glucose oxidase (GOx) was used in solution and functionalized on the VACNT surfaces by covalent bonding (with EDC/NHS) or by polymer entrapment (in PEDOT). With normalization by the projected cross-sectional area, the sensitivity of the enzyme-in-solution and covalent sensors were, respectively, 18.77 and 1.815 mA cm^-2 mM^-1. Corresponding limits of detection were 194 and 311 nM glucose. The linear sensing ranges for the sensors were: 500 nM – 200 μM for the enzyme-in-solution sensor and 1 μM – 6 mM glucose for the covalent sensor.
Enzyme-Based Glucose Detection with Flow-Through Carbon Nanotube Arrays
Orbital ATK Conference Center
Increased sensitivity of glucose sensors is important for enabling detection of very low glucose concentrations, such as that found in saliva. Free-standing, vertically-aligned carbon nanotubes (VACNTs) were patterned into 16 μm diameter microchannel arrays and then functionalized for flow-through electrochemical glucose sensing. Platinum nanowires (PNs) were deposited onto VACNT surfaces. The enzyme glucose oxidase (GOx) was used in solution and functionalized on the VACNT surfaces by covalent bonding (with EDC/NHS) or by polymer entrapment (in PEDOT). With normalization by the projected cross-sectional area, the sensitivity of the enzyme-in-solution and covalent sensors were, respectively, 18.77 and 1.815 mA cm^-2 mM^-1. Corresponding limits of detection were 194 and 311 nM glucose. The linear sensing ranges for the sensors were: 500 nM – 200 μM for the enzyme-in-solution sensor and 1 μM – 6 mM glucose for the covalent sensor.
Comments
Session 4