Relationships Between Catalase and Lifespan in Recombinant Inbred Strains of Caenorhabditis Elegans

Document Type

Article

Journal/Book Title/Conference

Journal of Nematology

Volume

35

Issue

3

Publication Date

2003

Keywords

Relationships Between Catalase and Lifespan in Recombinant Inbred Strains of Caenorhabditis Elegans

First Page

314

Last Page

319

Abstract

Johnson and Wood constructed recombinant inbred strains of Caenorhabditis elegans with life spans ranging from 10 to 31 days. Using these strains, we have demonstrated previously that hyperoxia and methyl viologen inhibited development at rates inversely correlated with life span. The growth rates of the short-lived recombinant inbred strains were more profoundly inhibited by oxidative stress than were those of the long-lived strains. Here we report a positive correlation between life span and catalase levels in these same strains. Specifically, when compared to short-lived strains at 10 days after fertilization, the long-lived strains possessed higher levels of total enzymatic catalase. Northern blots indicated a similar relationship between life span and clt-1mRNA (the cytosolic catalase). This suggests that at least some of the polygenes that influence life span are also responsible for regulating gene expression of catalase, an important defense component against oxidative stress.

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