Enhanced Antiscrapie Effect Using Combination Drug Treatment
Document Type
Article
Journal/Book Title/Conference
Antimicrobial Agents and Chemotherapy
Volume
50
Issue
10
Publisher
American Society for Microbiology
Publication Date
2006
First Page
3447
Last Page
3449
Abstract
Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases.
Recommended Citation
Kocisko, D.A., B. Caughey, J.D. Morrey, and R.E. Race 2006. Enhanced antiscrapie effect using combination drug treatment. Antimicrobial Agents and Chemotherapy. 50: 3447-3449.
COinS
Comments
Originally published by the American Society for Microbiology. Publisher's PDF and HTML fulltext available through remote link.