A Porphyrin Increases Survival Time of Mice after Intracerebral Prion Infection

Authors

D. A. Kocisko
W. S. Caughey
R. E. Race
G. Roper
B. Caughey
John D. Morrey, Utah State UniversityFollow

Document Type

Article

Journal/Book Title/Conference

Antimicrobial Agents and Chemotherapy

Volume

50

Issue

2

Publisher

American Society for Microbiology

Publication Date

2006

First Page

759

Last Page

761

Abstract

Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.

Comments

Originally published by the American Society for Microbiology. Publisher's PDF and HTML fulltext available through remote link.

Recommended Citation

Kocisko, D.A., W. S. Caughey, R.E. Race, G. Roper, B. Caughey, and J.D. Morrey 2006. A porphyrin increases survival time of mice after intracerebral prion infection. Antimicrobial Agents and Chemotherapy 50: 759-61.