A Porphyrin Increases Survival Time of Mice after Intracerebral Prion Infection
Document Type
Article
Journal/Book Title/Conference
Antimicrobial Agents and Chemotherapy
Volume
50
Issue
2
Publisher
American Society for Microbiology
Publication Date
2006
First Page
759
Last Page
761
Abstract
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
Recommended Citation
Kocisko, D.A., W. S. Caughey, R.E. Race, G. Roper, B. Caughey, and J.D. Morrey 2006. A porphyrin increases survival time of mice after intracerebral prion infection. Antimicrobial Agents and Chemotherapy 50: 759-61.
COinS
Comments
Originally published by the American Society for Microbiology. Publisher's PDF and HTML fulltext available through remote link.