Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice

Authors

Jonna B. Westover, Utah State UniversityFollow
Brady T. Hickerson, Utah State UniversityFollow
Arnaud J. Van Wettere, Utah State UniversityFollow
Brett L. Hurst, Utah State UniversityFollow
Jacqueline P. Kurz, Utah State UniversityFollow
Ashley Dagley, Utah State UniversityFollow
Petra Wülfroth, MChE-Trading Handels-GmbH
Takashi Komeno, FUJIFILM Toyama Chemical Co
Yousuke Furuta, FUJIFILM Toyama Chemical Co
Thomas Steiner, MChE-Trading Handels-GmbH
Brian B. Gowen, Utah State UniversityFollow

Document Type

Article

Journal/Book Title/Conference

Pathogens

Volume

8

Issue

4

Publisher

M D P I AG

Publication Date

9-21-2019

First Page

1

Last Page

17

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the pathogenesis and natural history of disease in IFNAR^-/- mice challenged with the HB29 strain of SFTS virus (SFTSV) and demonstrate hallmark features of VHF such as vascular leak and high concentrations of proinflammatory cytokines in blood and tissues. Treatment with FX06, a natural plasmin digest product of fibrin in clinical development as a treatment for vascular leak, reduced vascular permeability associated with SFTSV infection but did not significantly improve survival outcome. Further studies are needed to assess the role of vascular compromise in the SFTS disease process modeled in IFNAR^-/- mice.

Recommended Citation

Westover, J.B.; Hickerson, B.T.; Van Wettere, A.J.; Hurst, B.L.; Kurz, J.P.; Dagley, A.; Wülfroth, P.; Komeno, T.; Furuta, Y.; Steiner, T.; Gowen, B.B. Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice. Pathogens 2019, 8, 158.