Clearance and Excretion of Intratracheally and Orally Administered Aflatoxin B1 in the Rat

Authors

Roger A. Coulombe Jr., Utah State UniversityFollow
R. P. Sharma, Utah State University

Document Type

Article

Journal/Book Title/Conference

Food and Chemical Toxicology

Volume

23

Issue

9

Publisher

Elsevier

Publication Date

1985

First Page

827

Last Page

830

Abstract

The pharmacokinetic disposition of intratracheally (i/t) and orally administered [3H]AFBt was studied in male Sprague-Dawley rats. Blood, urine and faeces were collected at selected intervals following administration of a single i/t or oral dose of AFB1 (600 μg/kg) in saline. Blood-concentration data from both groups approximated a two-compartment open model. The time-to-peak for the i/t group (hr) was less than that for the oral group (3 hr), but the disappearance of label from the blood followed a nearly identical course in both groups. The plasma half-lives (Image ) were 87.7 and 91.8 hr for the i/t and oral groups, respectively. In addition, urinary and faecal excretion profiles were similar. By day 23, urinary excretion of label had accounted for 16.4 and 15.0% of the dose in the i/t and oral groups, respectively, and faecal excretion for 56.0 and 54.6%. At this time, however, significantly more label was recovered from the lungs and upper airways of the rats of the i/t group than in those treated orally.

Comments

Originally published by Elsevier. Publisher's PDF available through remote link.

Recommended Citation

Coulombe, R.A. and R.P. Sharma (1985). Clearance and excretion of intratracheally and orally administered aflatoxin B1 in the rat. Food Chem. Toxicol. 23:827-830.