Effect of Phosphonic Acid Analogs of Acyclovir and Ganciclovir on in Vitro Cytomegalovirus Infections

Document Type

Article

Journal/Book Title/Conference

Effect of phosphonic acidanalogs of acyclovir and ganciclovir on in vitro cytomegalovirus infections

Volume

8

Publication Date

1989

First Page

1159

Last Page

1160

Abstract

Eight phosphonic acid analogs of acyclovir (ACV) or ganciclovir (DHPG) inhibited human cytomegalovirus in vitro. Therapeutic indices were: phosphonate diacid of DHPG: 500; DHPG: 500; phosphonate monoethylester of DHPG: 258; phosphonate monoethylester of ACV: 94; cyclic phosphonate of DHPG: 64; ACV: 60; phosphonate monobutylester of ACV: 1.5; phosphonate monoethylester of deoxy DHPG: 4.6; 8-bromo ACV phosphonate monoethylester: >2; phosphonate monoethylester heptyl of ACV: 1. Types 1 and 2 herpesvirus (HSV-1, HSV-2) and varicella zoster virus (VZV) were poorly inhibited by these new compounds, suggesting highly specific anti-HCMV activity. None exhibited significant cytotoxic effects as measured by uptake of [3H]thymidine, [3H]uridine and [3H]leucine.

Comments

Nucleosides and Nucleotides. 8: 1159-1160

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