BbBSLS and BbBEAS were dissected and reconstituted in Saccharomyces cerevisiae. The intermodular linker is essential for the reconstitution of the separate modules. Module 1 can be swapped between BbBEAS and BbBSLS, while modules 2 and 3 control the product profiles. BbBSLS is a flexible enzyme that also synthesizes beauvericins.
Yu, Dayu; xu, fuchao; Gage, David; and Zhan, Jixun, "Functional dissection and module swapping of fungal cyclooligomer depsipeptide synthetases" (2013). Biological Engineering Faculty Publications. Paper 71.