"Synthesis of Kurasoin B Using Phase-Transfer-Catalyzed Acylimidazole A" by Michael A. Christiansen, Aaron W. Butler et al.
 

Synthesis of Kurasoin B Using Phase-Transfer-Catalyzed Acylimidazole Alkylation

Document Type

Article

Journal/Book Title

Synlett

Publication Date

2009

Publisher

Thieme Publishing

Volume

4

First Page

653

Last Page

657

Abstract

The hydroxy ketone natural product kurasoin B is synthesized using a phase-transfer-catalyzed alkylation reaction with benzyloxyacetyl imidazole. A biscinchonidinium dimethylnaphthalene catalyst allowed for high yield and near complete selectivity (99% ee) for the S-product using 3-methylbromoindole as the electrophile.

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