Date of Award:
12-2024
Document Type:
Dissertation
Degree Name:
Doctor of Philosophy (PhD)
Department:
Chemistry and Biochemistry
Committee Chair(s)
Ryan N. Jackson
Committee
Ryan N. Jackson
Committee
Chase L. Beisel
Committee
Sean J. Johnson
Committee
Nick E. Dickenson
Committee
Lance C. Seefeldt
Abstract
In the wake of the 2020 COVID19 pandemic, we have become acutely aware of the threat caused by viral infection. Humans are not alone in being threatened by viruses. Bacteria are under constant attack from viruses and have had to develop elaborate defense systems to protect themselves. As we learn about how bacteria defend themselves against viruses, we discover new biological pathways that can be repurposed as human technologies. One example is the bacterial immune system CRISPR – Cas9, which most think of as a genome editing tool. Here I describe a new immune system, CRISPR – Cas12a2 whose unique biochemical activity could be used for selective cell killing applications in biotechnology, agriculture and medicine.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Hallmark, Thomson, "Mechanisms Regulating Abortive Infection by CRISPR – Cas12a2" (2024). All Graduate Theses and Dissertations, Fall 2023 to Present. 383.
https://digitalcommons.usu.edu/etd2023/383
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