Date of Award
5-2024
Degree Type
Thesis
Degree Name
Departmental Honors
Department
Chemistry and Biochemistry
Abstract
Just as humans need to communicate with each other, our cells have a series of processes that allows them to communicate from one to another. Protein Arginine Methyltransferase I is an enzyme that helps mediate cellular communication by selectively binding to target proteins and performing chemistry that has broad-reaching downstream effects. However, the mechanisms that underly PRMT1 selectivity have yet to be elucidated. This study uses alterations to a series of known targets, called ribonucleoproteins, to identify some of the characteristics that govern recognition by the PRMT1 enzyme. I have made significant progress in the creation, expression, and purification of these targets that can be used to investigate binding to PRMT1.
Recommended Citation
Lonardo, Isabella Beverly, "An Investigation of Protein Arginine Methyltransferase 1 Substrate Recognition Through Ribonucleoprotein Modifications" (2024). Undergraduate Honors Capstone Projects. 979.
https://digitalcommons.usu.edu/honors/979
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Faculty Mentor
Joanie Hevel
Departmental Honors Advisor
Ryan Jackson