Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: the Cache County, Utah, study of memory and aging
Document Type
Article
Journal/Book Title/Conference
Neuropsychology
Volume
17
Issue
3
Publication Date
7-2003
First Page
339
Last Page
352
Abstract
Neuropsychological, qualitative, and quantitative magnetic resonance imaging findings were examined in subjects with Alzheimer's disease (AD), non-AD dementia or mixed neuropsychiatric disorder, subjects characterized as mild/ambiguous, and controls, all with known apolipoprotein E (APOE) genotype. Neuropsychological tasks included an expanded Consortium to Establish a Registery for Alzheimer's Disease (J. T. Tschanz et al., 2000; K. A. Welsh, J. M. Hoffman, N. L. Earl, & M. W. Hanson 1994) battery and the Mini-Mental Status Examination (M. F. Folstein, S. E. Folstein, & P. R. McHugh, 1975). Periventricular white matter lesions were the most clinically salient, and generalized measures of cerebral atrophy were the most significant quantitative indicators. APOE genotype was unrelated to imaging or neuropsychological performance. Neuropsychological relationships with neuroimaging findings depend on the qualitative or quantitative method used.
Recommended Citation
Bigler ED, Lowry C, Kerr B, Tate D, Hessel C, Earl H, Miller M, Smith K, Tschanz JT, Welsh-Bohmer K, Plassman B, Victoroff J. Role of white matter lesions, cerebral atrophy and APOE on cognition in Older Persons with and without dementia: The Cache County, Utah Study of Memory and Aging. Neuropsychology 2003;17: 339-352.
